Author Archive

The Immune System and Cancer: What is Cancer? Video Series

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Normally, immune cells detect and attack cancer cells. But some cancer cells can avoid detection or block an attack. Cancer treatments called immunotherapies help immune cells better detect and kill cancer.

This video has open captions.
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After a lifetime of debilitating infections, Tara Sakraida Parker found answers—and treatment—at Johns Hopkins, through immunologist Antoine Azar and the Center for Adult Primary Immunodeficiency Center.

Visit us: https://www.hopkinsmedicine.org/news/publications/hopkins_medicine_magazine/issues/winter-2019
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Entrenar Biceps y Triceps juntos? (Culturismo)

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Suscríbete Al Canal En Español
https://www.youtube.com/channel/UCYSNhtjA2Hw1KFoxiIb0uqw

Síguenos en Instagram!!
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#biceps #triceps #pesas

🤔 ¿Qué músculos se deben trabajar en el mismo día? 💪🏻 TRUCO ✅

🤔 ¿Qué músculos se deben trabajar en el mismo día? 💪🏻

¿QUE ENTRENAR CADA DIA DE LA SEMANA? ¿Cómo dividir su entrenamiento, porque hacerlo? TRUCO REVELADO!!

Espero que te ayuden estos consejos!! Te leo en los comentarios!! 💪🏻💪🏻

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IMMUNODEFICIENCIES | IMMUNODEFICIENCY DISORDERS

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Immunodeficiency means immune system is unable to protect the host from disease causing agents or from malignant cells.

#agaricus #immunodeficiency #immunodeficiencydisorders #primaryimmunodeficiency #secondaryimmunodeficiencies

PRIMARY IMMUNODEFICIENCY DISORDERS
https://youtu.be/-azY18Nz6u4

DENDRITIC CELL
https://youtu.be/DJ5On8GRwZw

AGRANULOCYTES
https://youtu.be/fMTpLypZsXA

GRANLOCYTES
https://youtu.be/YFeUI2-jiAY

PHAGOCYTOSIS
https://youtu.be/IoV7f_Iz5-U

Reference
https://amzn.to/3L6VASR
https://amzn.to/37Qg8AJ

Primary immunodeficiency disorders

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This is an overview of primary immunodeficiency disorders.

Graphics were created or adapted from Wikimedia Commons.
This presentation was created using Google Slides.

ADDITIONAL TAGS:
Selective IgA deficiency Hyper IgM syndrome X-linked Bruton’s agammaglobulinemia Common variable immunodeficiency C1 esterase inhibitor 22q112 deletion / DiGeorge Severe combined Wiskott–Aldrich Ataxia–telangiectasia Chronic granulomatous disease Leukocyte adhesion Chédiak–Higashi IgE Job Terminal complement C5-C9 Primary disorders B-cell humoral immunity deficiencies T-cell cellular lymphocyte and cellular phagocytosis Most common primary antibody Dx ↓ levels everything else normal normal IgG IgM B cells Related to CVID → similar arrest of cell differentiation Recurrent mouth airway respiratory infxns GI Giardia treat with abx Recall – mucus membranes still works so most patients are healthy asymptomatic undiagnosed benign Rarely presents severe rapid seconds minutes anaphylactic reaction following transfusion blood or IVIG Pathophys Anti-IgA antibodies against the new foreign Stop transfusion Give IM epi +/- bronchodilators antihistamines pressors mechanical ventilation If necessary give IgA-depleted Antibody class switching differentiation doesn’t work Cause absence CD40 ligand ↑ IgA nl cells Minimal nonselective defense Increased susceptibility recurrent sinopulmonary infxns Viruses encapsulated bacteria Treatment scheduled XLA recessive males only BTK gene mutation defective Bruton tyrosine kinase impaired maturation Ig production Signs/symptoms sinopulm Deficiency in opsonizing IgG otitis sinusitis pneumonia encapsulated Pseudomonas S pneumo Haemophilus Symptoms begin at 3-6 months transplacental maternal fades Small lymphoid tissue tonsils adenoids spleen lymph nodes enteroviral infxn Deficient response Diagnosis IgE Confirm flow cytometry B-cells low might say CD20+ low T-cells normal/high SCIG IVIG maybe prophylactic CVID abnormal plasma Decreased Presents adults children 15-35 yo as early puberty Males females resp lung sinus ear salmonella Campylobacter Giardia presentation lungs bronchiectasis fibrosis IBD-esque chronic diarrhea Less form XLA Need least two No vaccinations Upper lower Normal number B-cells but aka thymic aplasia velocardiofacial syndrome autosomal dominant CATCH-22 syndrome Cardiac defects tet fallot trunc art VSD Abnormal facial features micrognathia wide-spaced eyes low-set ears Thymic hypoplasia absent shadow T-cell deficiency Cleft palate craniofacial deformities Hypocalcemia hypoparathyroid seizures newborn tetany within chromosome 22q11 dev pharyngeal pouches Sx Infections viruses fungus Pneumocystis PCP PCP prophylaxis TMP/SMX bone marrow stem transplant Cure thymus SCID defect often adenosine deaminase failed development dysfunction Usually “bubble boy” no immune system starting 6 months Functionally AIDS Infections bacterial opportunistic PCP crypto candida toxo TB herpes chickenpox CMV PML diarrhea failure thrive Tx TMP/SMX English Wikipedia CC0 via Wikimedia Commons WAS protein Impaired cytoskeleton changes white cells platelets WIPE Infections thrombocytopenic Purpura Fig A Eczema B Bleeding hematoma A ear atopic diseases thrombocytopenia + splenectomy Low survival rates Cerebellar ataxia Incoordination stumbling falling slurred speech Oculocutaneous telangiectasia Recessive disease DNA repair predisp malignancy specific tx IVIG XLR NAPHD oxidase anion superoxides macrophages can ingest not kill catalase-positive organisms create granulomas instead respiratory GI UT skin infections granulomas ulcerations Catalase positive organisms Staph Aspergillus Burkholderia Nocardia Serratia Immune ↑ WBC can’t clear Measure neutrophil superoxide production Flow Dihydrorhodamine nitroblue tetrazolium test negative burst daily TMP/SMX antifungal itraconazole IFN-gamma CD18 integrin leukocyte chemotaxis Neutrophils adhere vessels exit impaired extravasation proliferates skin/mucosal skin GU pulm infections pus wounds high fever Newborns omphalitis inflammation umbilical stump delayed separation cord at 2-3 weeks old Lab WBC cytokines leukocytes high neutrophils Autosomal Lysosomes fuse together large granules neutrophils Peripheral neuropathy albinism skin eyes neutropenia for infections JAK-STAT signaling impairs Th17 proliferation FATED coarse Facies prominent forehead broad nose Abscesses cold noninflammatory containing S aureus Candida retained Teeth hyper-IgE Eosinophilia Derm severe eczema ↑↑ IgE eosinophilia Th17 otherwise membrane attack complex MAC which is required lysis Susceptible gram Neisseria meningococcal gonococcal antibiotics vaccines meningococcal Assembly MAC leads pores that disrupt target leading death hereditary angioedema AD deno excess bradykinin fluid accumulates mucosa trauma stress? ACEi NSAIDs Distinct from anaphylaxis no pruritus urticaria Not allergic mediated antihistamines don’t help GI abd pain n/v/d Resp laryngospasm obstruction increased risk but related
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Bicep – The Friday Guest Mix – 02 December 2022 | BBC Radio 6 Music | Mary Anne Hobbs Show

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Bicep - The Friday Guest Mix - 02 December 2022 | BBC Radio 6 Music | Mary Anne Hobbs Show

Bicep – The Friday Guest Mix – 02 December 2022 | BBC Radio 6 Music | Mary Anne Hobbs Show ★ electronica, experimental ★ Guest Mix, DJ Music ★ TRACKLIST on INSTAGRAM: Triplestar_11
📣 Support #Sensationmusic for what we do!
💳 💰 You can send money via PayPal (e-mail: valerydenga@ukr.net)

#Bicep #FridayGuestMix #TheFridayGuestMix #MaryAnneHobbsShow #BBCRadio6Music #BBC #Radio6 #BBCSounds #experimental #electronica #Bicep2022

(How to create Azure resources using bicep files)
In this video I demonstrate how you can create resources using bicep files instead of json files. I also demonstrate how you can convert a JSON file to a bicep file.

Using bicep files is really great for managing azure resources.

*using bicep files in azure
*create a storage account with bicep and powershell
*decompile JSON to bicep
*param in bicep file
*Automation azure
*azure automation
*azure bicep
*azure json
*transpile json to bicep
*powershell
*learn powershell
*automation
*learn automation
*windows
*windows powershell
*automatic deployment
*automatic installations
*configuration as code

Code df :
var location = resourceGroup().location
param tag2 string = ‘value2-default’

resource mydf ‘Microsoft.DataFactory/factories@2018-06-01’ = {
name: ‘myaf’
location: location
tags: {
tag1: ‘value1’
tag2: tag2
}
}

Code storage accounts:
param tag2 string = ‘value2-default’
param stname string = ‘mrb2411’
var sku = ‘Standard_LRS’
var kind = ‘StorageV2’

resource mystorageacc ‘Microsoft.Storage/storageAccounts@2021-04-01’ = {
name: stname
location: resourceGroup().location
tags:{
tag1: ‘value1’
tag2: tag2
}
sku: {
name: sku
}
kind: kind
}

Powershell wrapper for account creation:
for ($ i =0; $ i -lt 10; $ i++){
New-AzResourceGroupDeployment -TemplateFile part.bicep `
-stname “mrb2412$ i” -tag2 “overwrited value $ i”

}

Export resourcegroup to JSON
Export-AzResourceGroup -ResourceGroupName “name_rg”

deploy a bicep : New-AzResourceGroupDeployment -TemplateFile .\df.bicep

decompile: bicep decompile filepath.json

Choose the Right Climbing Rose

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Picking the right climbing rose for your garden can be a bit overwhelming with so many great climbers and ramblers to choose from. In this video, I’ll highlight some of the most popular and sought-after varieties of climbing roses, including some from David Austin, others from Kordes and Meilland. I’ll also discuss the basics of how to train them in the landscape.

If you find these videos useful, there are a few little things you can do to help me out:

Have a look at our Amazon shop: https://www.amazon.com/shop/fraservalleyrosefarm

Follow our farm on Instagram: https://www.instagram.com/fraservalleyrosefarm
Like us on Facebook: https://www.facebook.com/FraserValleyRoseFarm

Or better yet, subscribe to this Youtube channel: https://www.youtube.com/c/FraserValleyRoseFarm?sub_confirmation=1

And for a place to indulge in random garden anarchy: https://www.facebook.com/groups/unrulyrosesociety/

Photo Credits:

New Dawn by © 1971markus CC BY-SA 4.0
Don Juan by Ann reg CC BY-SA 3.0 AT
Laguna by CC BY-SA 4.0
Polka (own)
Westerland by CC BY-SA 3.0
Rosarium Uetersen by T. Kiya CC BY-SA 2.0
Eden by Geolina163 CC BY-SA 4.0
Roberta Bondar (own)
Florentina by Salicyna CC BY-SA 4.0
Souvenir du Docteur Jamain (own)
Sally Holmes (own)
Ghislaine de Feligonde (own)
Gertrude Jekyll by Andy Mabbett CC BY-SA 3.0
The Pilgrim by Leonora (Ellie) Enking CC BY-SA 2.0
Albertine by Spedona CC BY-SA 3.0
Buff Beauty (own)
Lady Banks by Acabashi CC BY-SA 4.0
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Primary Immunodeficiency: Introduction, Cellular Distribution & Background – Immunology | Lecturio

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This video “Primary Immunodeficiency: Introduction, Cellular Distribution & Background” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/immunology6

► LEARN ABOUT:
– Introduction to Immunodeficiency
– Distribution of Cellular Primary Immunodeficiency Defects
– Primary Immunodeficiency Background
– X-Linked Primary Immunodeficiencies

► THE PROF:
Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.

► LECTURIO is your single-point resource for medical school:
Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: http://lectur.io/immunology6

► INSTALL our free Lecturio app
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► READ TEXTBOOK ARTICLES related to this video:
Primary Immunodeficiency
http://lectur.io/immunodeficiencyarticle

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► WATCH MORE ON YOUTUBE: http://lectur.io/playlists

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• Twitter: https://twitter.com/LecturioMed
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Primary antibody deficiency - Common Variable Immunodeficiency (CVID) , X-linked agammaglobulinemia

Buy PDFs here: http://armandoh.org/shop

“Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired b cells such as common variable immune deficiency (CVID) or have selective antibody deficiency with abnormalities in shape and structure such as IgA deficiency.

For suspected antibody immunodeficiency disease important to measure immunoglobulins: Serum IgA, IgM and IgG subclasses and lymphocytes count and subsets. Remember to exclude secondary cause of low Immunoglobulins”

Support me:
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Warning from German Health Minister!! – Immunodeficiency after COVID infection

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Headline NTV/Politics – 21st January 2023:

Lauterbach warns of incurable immune deficiency caused by Corona
https://www.n-tv.de/politik/Lauterbach-warnt-vor-unheilbarer-Immunschwaeche-durch-Corona-article23860527.html
(Translate to English)

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
https://www.nature.com/articles/s41392-021-00749-3

The bigger question is, why now??

Read the explanation on Substack:
https://philipmcmillan.substack.com/p/warning-from-german-health-minister
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Fungal Arthritis, Causes, Signs and Symptoms, Diagnosis and Treatment.

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.

Chapters

0:00 Introduction
0:59 Causes of Fungal Arthritis
2:24 Symptoms of Fungal Arthritis
2:38 Diagnosis of Fungal Arthritis
3:17 Treatment of Fungal Arthritis

Fungal arthritis is a rare medical condition characterized by the swelling and inflammation of a joint brought by a fungus microorganism that has invaded the body.
• There are 50,000 to 200,000 species of fungi, but only about 100 of these cause infectious diseases in humans.
• This condition most commonly affects the knee joint, although other joints may also be affected.
• Fungal infection of the joint is a very serious condition that can lead to permanent damage to the joint with loss of function, if not treated urgently and properly
• Fungal organisms that can cause fungal arthritis include Aspergillus, Candida, and Exserohilum species
• Fungal arthritis, also called mycotic arthritis affects both adult men and women of any age.

CAUSES
Fungi arthritis can be caused by any of the invasive types of fungi. The infection can result from directly injecting medications that is contaminated by fungus into the joint. In some cases, a joint can also be infected as a result of contaminated prosthesis used in joint replacement surgery. The condition can also be due to infection in an organ, such as the lungs and intestines that travels to the joint through the bloodstream
Conditions (fungal infections) that can cause fungal arthritis include:
• Candidiasis
• Sporotrichosis
• Coccidioidomycosis
• Blastomycosis
• Exserohilum rostratum, this type is the one caused by injecting the joint with a contaminated medication or vial. This, in fact, was the situation in September 2012 when contaminated vials of medications produced by a compounding pharmacy caused a multistate outbreak of rare and fungal arthritis

Risk factors associated with the condition include:
• Having a weakened immune system due to HIV/AIDS, cancer, organ transplant, or diabetes. The risk increases if such person travels to, live, or stay in fungus endemic areas. The growth of fungus is common in geographical regions with warm and humid climate condition.

SYMPTOMS
• Pain, stiffness, and swelling of the joint
• Fever
• Swelling of the ankles, feet, and legs
• Restricted range of motion of affected joint

DIAGNOSIS AND TREATMENT
To make a diagnosis, the doctor will carry out a complete evaluation of medical history, thorough physical and joint examination. During the physical examination, the doctor may look for swelling, redness, warmth of joint, and check for range of motion.
Other diagnostic options include:
• Removal of joint fluid to look for fungus under a microscope
• X-ray of the joints
• Positive antibody test for fungal disease
• Culture of the joint fluid
• Synovial biopsy showing fungus
TREATMENT
The goal of the treatment option is to cure the infection. Fungal infection responds well to treatment with antifungal medications
In severe cases of bone or joint infection, surgery may be required to remove the infected tissue.
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I tried the world's biggest climbing gym // With Alexis Landot

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Check out @AlexisLandot and the gym climbing gym https://aubervilliers.climb-up.fr

My clothing brand: https://rungne.com

Filmed by Rolf Martin Bjørngaard & Edited by Magnus Midtbø

Music and Sound Effects: http://share.epidemicsound.com/vSnfn​

I went to the biggest indoor climbing gym in the world with Alexis Landot
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