Archive for the tag: immunodeficiency

Warning from German Health Minister!! – Immunodeficiency after COVID infection

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Headline NTV/Politics – 21st January 2023:

Lauterbach warns of incurable immune deficiency caused by Corona
https://www.n-tv.de/politik/Lauterbach-warnt-vor-unheilbarer-Immunschwaeche-durch-Corona-article23860527.html
(Translate to English)

SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism
https://www.nature.com/articles/s41392-021-00749-3

The bigger question is, why now??

Read the explanation on Substack:
https://philipmcmillan.substack.com/p/warning-from-german-health-minister
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Lessons in Autoimmunity from the World of Primary Immunodeficiency Disease

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This webcast will review the association between type I interferons and the development of lupus and vasculitis. Alterations in immune cell signaling and autoimmunity and immune dysregulation will also be discussed. The roll of regulatory T cells in maintain immune tolerance and preventing immune dysregulation will be reviewed as well.
Visit http://www.ccfcme.org/bioviicmevideos to claim CME credit or learn more about the Biologic Therapies VII series.

The webcast features expert faculty member, Dr. Troy R. Torgerson, of Seattle Children’s Research Institute

The video was produced by the Cleveland Clinic Foundation Center for Continuing Education and RJ Fasenmyer Center for Clinical Immunology.

Interested in related CME education? Visit http://www.ccfcme.org/rheumcme
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Brief description of autoimmune diseases and immunodeficiency diseases
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Human Immunodeficiency Virus (HIV)

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Human Immunodeficiency Virus (HIV) is quite the infamous virus, which rose to notoriety in the 1980s once it was discovered to be the cause of AIDS, a terrible disorder of the immune system. HIV is a retrovirus, so what does that mean, and how does that make the virus special? What does it do, and precisely how does it cause AIDS? This is good information for anyone to know, so let’s get a closer look now.

Script by Kellie Vinal

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Autoimmunity & Immunodeficiency – What's the Relationship?

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IDF 2015 National Conference session, “Autoimmunity & Immunodeficiency – What’s the Relationship?” was presented by Kathleen Sullivan, MD, PhD on June 26, 2015.

SCID (Severe combined immunodeficiency) || symptoms and immunology || Immunodeficiency

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Severe combined immunodeficiency (SCID) is a group of rare disorders caused by mutations in different genes involved in the development and function of infection-fighting immune cells. Infants with SCID appear healthy at birth but are highly susceptible to severe infections.

Severe combined immunodeficiency – A deadly combination of defects of T & B lymphocytes + Natural killer cells

Its a primary immunodeficiency (inherited in the family) affecting T lymphoocytes, B lymphocytes and Natural killer cells in different combinations.

These children die within one year without a bone marrow transplantation.There have been cases like “David the bubble boy” who survived for 12 years in a sterile chamber isolated from pathogens.

Patients are small babies that suffers from fungal, bacterial, or viral infections since their immune system is not functioning as it should.

The symptoms can be:
recurrent infections resistant to antibiotics,
failure to thrive with abnormal growth curves,
diarrhea,
diaper rash,
bronchitis,
pneumonia,
otitis media,
liver abscess,
morbilliform rash,
oral candidiasis

Doctors can check the sequence of DNA to determine any mutations that would cause this disease.
One have to remember that the levels of antibodies decline after about 6 month of age if the baby fails to produce new ones for himself, since the antibodies from the mother are depleted.
So these babies may appear healthy for about 6 months.
Therefore we can check blood values of lymphocytes, natural killer cells and antibodies to easier determine which type of Severe combined immunodeficiency we are dealing with.

What are the types of this disease?
Mainly X linked recessive (IL2RG gene mutation at Xq13.1) and autosomal recessive .

The autosomal recessive have many types:
adenosine deaminase deficiency,
Jak3 intracellular kinase mutation,
Purine nucleoside phosphorylase mutation,
Omenn syndrome with RAG gene mutation,
Bare lymphocyte syndrome with MHC 2 gene mutation.

The adenosine deaminase deficiency cause an accumulation of dATP, which blocks the enzyme Ribonucleotide reductase (converts NDP to dNDP). Without dNDP there is no DNA synthesis and therefore no production of cells like T & B lymphocytes.

You can imagine that without T & B cells there is no real immunity against infections. We can see depleted zones in the hypoplastic lymphoid organs. One example being a small thymus lacking lymphocytes and Hassall’s corpuscles. On X-ray there is an abscence of thymic shadow.

The treatment?
Bone marrow transplantation and gene therapy. About 1 patient out of 5 have a risk of getting acute T cell leukemia when treated with bone marrow transplantation.

These videos are for informational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any Nordic Health Organization video.
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