Archive for the tag: immunodeficiency

Annual World Primary Immunodeficiency Week and Covid-19

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A primary immunodeficiency disorder compromises the immune system and prevents the body from fighting off any infection or disease. During this time of Covid-19 a strong immune system is key and those who suffer from any immunodeficiency disease could be at an increased risk. The Annual World Primary Immunodeficiency Week has this year been extended to 10 weeks from 22 April to the 1st of July to raise awareness for those living with any of these diseases. Professor Claudia Gray, Paediatric Allergy Specialist at Red Cross Children’s Hospital & UCT Lung Institute joins us this morning to tell us more about the link between PID and Covid-19.

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Quiz about Atopic Dermatitis, Eczema, and Noninfectious Immunodeficiency Disorders | Part 2

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31 quizzes about Atopic Dermatitis, Eczema, and Noninfectious Immunodeficiency Disorders – Part 2. Each quiz is an image for you to identify situations such as Pompholyx, Id reaction, Xerotic eczema, Nummular eczema, Job’s syndrome, Ataxia telangiectasia, Granulomatous lesions, Common variable immunodeficiency, Warts in DOCK8, Acute graft-versus-host disease, Acute graft-versus-host disease grade 2, Chronic graft-versus-host disease, Fasciitis in graft-versus-host disease, Sclerodermoid graft-versus-host disease, and more… All questions have answers.
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A Family Affair: One Family’s Journey with Severe Combined Immunodeficiency (SCID)

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Severe Combined Immunodeficiency (SCID) is a potentially fatal primary immunodeficiency. This condition is generally considered to be the most serious of the primary immunodeficiencies. Today, early identification of SCID can make possible life-saving interventions. Join the Immune Deficiency Foundation as we speak with Nicole Locastro, a mother of a child diagnosed with SCID through newborn screening. Nicole offers us some thoughtful insights into the family experience and some strategies her family employed along the way.

There's a misconception circulating that COVID-19 causes immunodeficiency. This is not the case

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There is a recent misconception circulating that COVID-19 causes immunodeficiency. The TL;DR: this is not the case.

Immunodeficiency occurs when one (or both) arms of the adaptive immune system are not functioning properly. This means that individuals become susceptible for a broad array of opportunistic illnesses. These include infections with microorganisms that would normally not cause disease in most healthy individuals.

These include:

Pneumocystis pneumonia: serious respiratory illness caused by fungal infection by the pathogen Pneumocystis jirovecii

Tuberculosis: caused by the bacterium Mycobacterium tuberculosis. Typically very rare, infection risk increases if someone’s immune system is not functioning properly.

Coccidioidomycosis: also called valley fever, this is another infection with a fungus found in the soil.

Cryptosporidiosis: a parasitic infection that can cause diarrhea and other severe GI symptoms

These types of illnesses are not occurring after recovery from COVID-19. T cells are not being “wiped out” after COVID-19. Yes, there is some evidence that some individuals have temporary immune system changes or perturbations after infection with SARS-CoV-2, but that is not the same as immunodeficiency, and is also not unique to this virus. More on this topic soon!

Winter respiratory illnesses such as RSV and influenza are not opportunistic infections. We’ve chatted about some reasons why there is increased infection activity previously, so check that out too.

Please be careful who you consume information from – misleading info is everywhere.

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Watch this IDF Forum recording to hear Alexandra Freeman, MD discuss COVID-19 and how it could affect people with primary immunodeficiency. This meeting was presented on April 13, 2020.
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107P Severe Combined Immunodeficiency, Wiskott Aldrich Syndrome

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Severe combined immunodeficiency (SCID) represents a constellation of genetically distinct syndromes with the common feature of defects in both humoral and cell-mediated immune responses. Affected infants are susceptible to severe recurrent infections by a wide array of pathogens, including bacteria, viruses, fungi, and protozoans; opportunistic infections by Candida, Pneumocystis, CMV, and Pseudomonas also cause serious (and occasionally lethal) disease.

Wiskott-Aldrich syndrome is an X-linked recessive disease characterized by thrombocytopenia, eczema, and a marked vulnerability to recurrent infection, ending in early death; the only treatment is bone marrow transplantation.

Dr. Becker Discusses Feline Immunodeficiency Virus (FIV)

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http://healthypets.mercola.com/sites/healthypets/archive/2016/01/10/feline-immunodeficiency-virus.aspx?x_cid=youtube Dr. Karen Becker, a proactive and integrative wellness veterinarian, talks about feline immunodeficiency virus (FIV), a lentivirus, or “slow virus,” that multiplies slowly and has a long incubation period before causing symptoms.

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Hey friends, feline immunodeficiency virus (FIV) is one of the most common diseases in the feline population, often grouped with other viruses like feline leukaemia and feline infectious peritonitis. Today we chat through what fiv is and what it means for your feline furr-iend if they have fiv!
If you stumbled on this video I hope you and your furkids are healthy and well. ❤️

⏰Timestamps
0:00 intro
0:52 what we will cover
1:05 how is feline immunodeficiency virus (fiv) transmitted?
1:54 fiv pathogenesis
3:15 brain break
4:03 can your fiv cat live with other healthy cats at home?
4:27 research paper 1
5:50 research paper 2
6:11 managing your fiv positive cat
7:03 research paper 3
7:60 how I keep my cat, Keith healthy tips and advice

📖 References:
1. Transmission of feline immunodeficiency virus (FIV) among cohabiting cats in two cat rescue shelters (paper 1) https://www.sciencedirect.com/science/article/pii/S1090023314000847
2. Management and multicat household study (paper 2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332694/
3. Clinical Findings and Survival in Cats Naturally Infected with Feline Immunodeficiency Virus https://onlinelibrary.wiley.com/doi/full/10.1111/jvim.12120

📖Other sources:
– FIV QnA video https://youtu.be/0YsQ1PV2Itw?si=SJkjYj2LV2igXVTY
– ABCD guidelines on prevention and management https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129779/
– https://www.humanesociety.org/news/fiv-positive-cats
– Feline environment guidelines https://journals.sagepub.com/doi/10.1177/1098612X13477537, https://www.cats.org.uk/help-and-advice/home-and-environment/indoor-cats

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Severe Combined Immunodeficiency

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Morton Cowan, MD, reviews the history, diagnosis and management of Severe Combined Immunodeficiency (SCID). Recorded on 12.19.2014. [6/2015] [Show ID: 29421]

Please Note: Knowledge about health and medicine is constantly evolving. This information may become out of date.

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Savannah was a good friend of the Immune Deficiency Foundation, and we continue to celebrate her life through this video.

GROUNDBreaking Stories are your words, your videos, your stories. By sharing experiences, you can inspire each other. The stories cover all sorts of topics, whether it’s school, primary immunodeficiency (PI) and treatment, or just everyday life.
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IMMUNODEFICIENCIES | IMMUNODEFICIENCY DISORDERS

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Immunodeficiency means immune system is unable to protect the host from disease causing agents or from malignant cells.

#agaricus #immunodeficiency #immunodeficiencydisorders #primaryimmunodeficiency #secondaryimmunodeficiencies

PRIMARY IMMUNODEFICIENCY DISORDERS
https://youtu.be/-azY18Nz6u4

DENDRITIC CELL
https://youtu.be/DJ5On8GRwZw

AGRANULOCYTES
https://youtu.be/fMTpLypZsXA

GRANLOCYTES
https://youtu.be/YFeUI2-jiAY

PHAGOCYTOSIS
https://youtu.be/IoV7f_Iz5-U

Reference
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Primary immunodeficiency disorders

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This is an overview of primary immunodeficiency disorders.

Graphics were created or adapted from Wikimedia Commons.
This presentation was created using Google Slides.

ADDITIONAL TAGS:
Selective IgA deficiency Hyper IgM syndrome X-linked Bruton’s agammaglobulinemia Common variable immunodeficiency C1 esterase inhibitor 22q112 deletion / DiGeorge Severe combined Wiskott–Aldrich Ataxia–telangiectasia Chronic granulomatous disease Leukocyte adhesion Chédiak–Higashi IgE Job Terminal complement C5-C9 Primary disorders B-cell humoral immunity deficiencies T-cell cellular lymphocyte and cellular phagocytosis Most common primary antibody Dx ↓ levels everything else normal normal IgG IgM B cells Related to CVID → similar arrest of cell differentiation Recurrent mouth airway respiratory infxns GI Giardia treat with abx Recall – mucus membranes still works so most patients are healthy asymptomatic undiagnosed benign Rarely presents severe rapid seconds minutes anaphylactic reaction following transfusion blood or IVIG Pathophys Anti-IgA antibodies against the new foreign Stop transfusion Give IM epi +/- bronchodilators antihistamines pressors mechanical ventilation If necessary give IgA-depleted Antibody class switching differentiation doesn’t work Cause absence CD40 ligand ↑ IgA nl cells Minimal nonselective defense Increased susceptibility recurrent sinopulmonary infxns Viruses encapsulated bacteria Treatment scheduled XLA recessive males only BTK gene mutation defective Bruton tyrosine kinase impaired maturation Ig production Signs/symptoms sinopulm Deficiency in opsonizing IgG otitis sinusitis pneumonia encapsulated Pseudomonas S pneumo Haemophilus Symptoms begin at 3-6 months transplacental maternal fades Small lymphoid tissue tonsils adenoids spleen lymph nodes enteroviral infxn Deficient response Diagnosis IgE Confirm flow cytometry B-cells low might say CD20+ low T-cells normal/high SCIG IVIG maybe prophylactic CVID abnormal plasma Decreased Presents adults children 15-35 yo as early puberty Males females resp lung sinus ear salmonella Campylobacter Giardia presentation lungs bronchiectasis fibrosis IBD-esque chronic diarrhea Less form XLA Need least two No vaccinations Upper lower Normal number B-cells but aka thymic aplasia velocardiofacial syndrome autosomal dominant CATCH-22 syndrome Cardiac defects tet fallot trunc art VSD Abnormal facial features micrognathia wide-spaced eyes low-set ears Thymic hypoplasia absent shadow T-cell deficiency Cleft palate craniofacial deformities Hypocalcemia hypoparathyroid seizures newborn tetany within chromosome 22q11 dev pharyngeal pouches Sx Infections viruses fungus Pneumocystis PCP PCP prophylaxis TMP/SMX bone marrow stem transplant Cure thymus SCID defect often adenosine deaminase failed development dysfunction Usually “bubble boy” no immune system starting 6 months Functionally AIDS Infections bacterial opportunistic PCP crypto candida toxo TB herpes chickenpox CMV PML diarrhea failure thrive Tx TMP/SMX English Wikipedia CC0 via Wikimedia Commons WAS protein Impaired cytoskeleton changes white cells platelets WIPE Infections thrombocytopenic Purpura Fig A Eczema B Bleeding hematoma A ear atopic diseases thrombocytopenia + splenectomy Low survival rates Cerebellar ataxia Incoordination stumbling falling slurred speech Oculocutaneous telangiectasia Recessive disease DNA repair predisp malignancy specific tx IVIG XLR NAPHD oxidase anion superoxides macrophages can ingest not kill catalase-positive organisms create granulomas instead respiratory GI UT skin infections granulomas ulcerations Catalase positive organisms Staph Aspergillus Burkholderia Nocardia Serratia Immune ↑ WBC can’t clear Measure neutrophil superoxide production Flow Dihydrorhodamine nitroblue tetrazolium test negative burst daily TMP/SMX antifungal itraconazole IFN-gamma CD18 integrin leukocyte chemotaxis Neutrophils adhere vessels exit impaired extravasation proliferates skin/mucosal skin GU pulm infections pus wounds high fever Newborns omphalitis inflammation umbilical stump delayed separation cord at 2-3 weeks old Lab WBC cytokines leukocytes high neutrophils Autosomal Lysosomes fuse together large granules neutrophils Peripheral neuropathy albinism skin eyes neutropenia for infections JAK-STAT signaling impairs Th17 proliferation FATED coarse Facies prominent forehead broad nose Abscesses cold noninflammatory containing S aureus Candida retained Teeth hyper-IgE Eosinophilia Derm severe eczema ↑↑ IgE eosinophilia Th17 otherwise membrane attack complex MAC which is required lysis Susceptible gram Neisseria meningococcal gonococcal antibiotics vaccines meningococcal Assembly MAC leads pores that disrupt target leading death hereditary angioedema AD deno excess bradykinin fluid accumulates mucosa trauma stress? ACEi NSAIDs Distinct from anaphylaxis no pruritus urticaria Not allergic mediated antihistamines don’t help GI abd pain n/v/d Resp laryngospasm obstruction increased risk but related
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Primary Immunodeficiency: Introduction, Cellular Distribution & Background – Immunology | Lecturio

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This video “Primary Immunodeficiency: Introduction, Cellular Distribution & Background” is part of the Lecturio course “Immunology” ► WATCH the complete course on http://lectur.io/immunology6

► LEARN ABOUT:
– Introduction to Immunodeficiency
– Distribution of Cellular Primary Immunodeficiency Defects
– Primary Immunodeficiency Background
– X-Linked Primary Immunodeficiencies

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Peter Delves, Professor Emeritus of Immunology and former Vice Dean (Education) of the Faculty of Medical Sciences at University College London, is not only editor of two encyclopedias but also author of several textbooks and laboratory manuals. His special interest lies in improving an understanding of immunology through both web-based education and face-to-face interaction.

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Primary antibody deficiency - Common Variable Immunodeficiency (CVID) , X-linked agammaglobulinemia

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“Examples of antibody deficiencies include when you have absent B cells such as X-linked agammaglobulinemia, impaired b cells such as common variable immune deficiency (CVID) or have selective antibody deficiency with abnormalities in shape and structure such as IgA deficiency.

For suspected antibody immunodeficiency disease important to measure immunoglobulins: Serum IgA, IgM and IgG subclasses and lymphocytes count and subsets. Remember to exclude secondary cause of low Immunoglobulins”

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