Archive for the tag: Causes

HIV & AIDS – signs, symptoms, transmission, causes & pathology

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What are HIV and AIDS? HIV, or human immunodeficiency virus, is a virus that targets cells in the immune system. Over time, the immune system begins to fail which is called immunodeficiency, and this increases the risk of infections and tumors that a healthy immune system would usually be able to fend off. These complications are referred to as AIDS, or acquired immunodeficiency syndrome.

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There's a misconception circulating that COVID-19 causes immunodeficiency. This is not the case

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There is a recent misconception circulating that COVID-19 causes immunodeficiency. The TL;DR: this is not the case.

Immunodeficiency occurs when one (or both) arms of the adaptive immune system are not functioning properly. This means that individuals become susceptible for a broad array of opportunistic illnesses. These include infections with microorganisms that would normally not cause disease in most healthy individuals.

These include:

Pneumocystis pneumonia: serious respiratory illness caused by fungal infection by the pathogen Pneumocystis jirovecii

Tuberculosis: caused by the bacterium Mycobacterium tuberculosis. Typically very rare, infection risk increases if someone’s immune system is not functioning properly.

Coccidioidomycosis: also called valley fever, this is another infection with a fungus found in the soil.

Cryptosporidiosis: a parasitic infection that can cause diarrhea and other severe GI symptoms

These types of illnesses are not occurring after recovery from COVID-19. T cells are not being “wiped out” after COVID-19. Yes, there is some evidence that some individuals have temporary immune system changes or perturbations after infection with SARS-CoV-2, but that is not the same as immunodeficiency, and is also not unique to this virus. More on this topic soon!

Winter respiratory illnesses such as RSV and influenza are not opportunistic infections. We’ve chatted about some reasons why there is increased infection activity previously, so check that out too.

Please be careful who you consume information from – misleading info is everywhere.

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Watch this IDF Forum recording to hear Alexandra Freeman, MD discuss COVID-19 and how it could affect people with primary immunodeficiency. This meeting was presented on April 13, 2020.
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Rheumatoid arthritis – causes, symptoms, diagnosis, treatment, pathology

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What is rheumatoid arthritis? Rheumatoid arthritis is an autoimmune condition where the immune system attacks the joints.

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Fungal Arthritis, Causes, Signs and Symptoms, Diagnosis and Treatment.

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Chapters

0:00 Introduction
0:59 Causes of Fungal Arthritis
2:24 Symptoms of Fungal Arthritis
2:38 Diagnosis of Fungal Arthritis
3:17 Treatment of Fungal Arthritis

Fungal arthritis is a rare medical condition characterized by the swelling and inflammation of a joint brought by a fungus microorganism that has invaded the body.
• There are 50,000 to 200,000 species of fungi, but only about 100 of these cause infectious diseases in humans.
• This condition most commonly affects the knee joint, although other joints may also be affected.
• Fungal infection of the joint is a very serious condition that can lead to permanent damage to the joint with loss of function, if not treated urgently and properly
• Fungal organisms that can cause fungal arthritis include Aspergillus, Candida, and Exserohilum species
• Fungal arthritis, also called mycotic arthritis affects both adult men and women of any age.

CAUSES
Fungi arthritis can be caused by any of the invasive types of fungi. The infection can result from directly injecting medications that is contaminated by fungus into the joint. In some cases, a joint can also be infected as a result of contaminated prosthesis used in joint replacement surgery. The condition can also be due to infection in an organ, such as the lungs and intestines that travels to the joint through the bloodstream
Conditions (fungal infections) that can cause fungal arthritis include:
• Candidiasis
• Sporotrichosis
• Coccidioidomycosis
• Blastomycosis
• Exserohilum rostratum, this type is the one caused by injecting the joint with a contaminated medication or vial. This, in fact, was the situation in September 2012 when contaminated vials of medications produced by a compounding pharmacy caused a multistate outbreak of rare and fungal arthritis

Risk factors associated with the condition include:
• Having a weakened immune system due to HIV/AIDS, cancer, organ transplant, or diabetes. The risk increases if such person travels to, live, or stay in fungus endemic areas. The growth of fungus is common in geographical regions with warm and humid climate condition.

SYMPTOMS
• Pain, stiffness, and swelling of the joint
• Fever
• Swelling of the ankles, feet, and legs
• Restricted range of motion of affected joint

DIAGNOSIS AND TREATMENT
To make a diagnosis, the doctor will carry out a complete evaluation of medical history, thorough physical and joint examination. During the physical examination, the doctor may look for swelling, redness, warmth of joint, and check for range of motion.
Other diagnostic options include:
• Removal of joint fluid to look for fungus under a microscope
• X-ray of the joints
• Positive antibody test for fungal disease
• Culture of the joint fluid
• Synovial biopsy showing fungus
TREATMENT
The goal of the treatment option is to cure the infection. Fungal infection responds well to treatment with antifungal medications
In severe cases of bone or joint infection, surgery may be required to remove the infected tissue.
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