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Chediak-Higashi vs. Chronic Granulomatous vs. Leukocyte Adhesion vs. Wiskott-Aldrich

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Chediak-Higashi vs. Chronic Granulomatous vs. Leukocyte Adhesion vs. Wiskott-Aldrich

​​SUPPORT/JOIN THE CHANNEL: https://www.youtube.com/channel/UCZaDAUF7UEcRXIFvGZu3O9Q/join

My goal is to reduce educational disparities by making education FREE.
These videos help you score extra points on medical school exams (USMLE, COMLEX, etc.)
For educational purposes only; NOT medical or other advice.
Some videos contain mild profanity and hyperbole solely used to assist with memorization. Viewer discretion advised.
Opinions are entirely my own.
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This Is Why You Need Climbing Trousers | Climbing Daily Ep.1026

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Get 15% off ALL clothes on the EpicTV shop with the code EPICLOOK15.
Shop here: https://bit.ly/2KOVHFH

Offer Ends Sunday 03rd May Midnight

Let’s be honest climbing trousers are probably an essential item in your climbing cupboard. There is a vast amount to choose from and different types available for each climbing activity. So what type do you need for you climbing needs…?

RAB Capstone Pants: https://goo.gl/LPh9TW
Prana Axiom jeans: https://goo.gl/niVTay
Arc’teryx Gamma Pants: https://goo.gl/pRjHKe
Norrona Falketind: https://goo.gl/No8LFj

This Is Why You Need Climbing Trousers | Climbing Daily Ep.1026
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Full Playlist: https://www.youtube.com/playlist?list=PLLALQuK1NDrjugIQA3Te01g3ksXghWCMR


Rockin’ Rock Climbing Commodities
Momentum Climbing Harness: http://amzn.to/1iN4Caq
La Sportiva Tarantulace Men’s Climbing Shoe: http://amzn.to/1FL2Qvz
La Sportiva Tarantulace Women’s Climbing Shoe: http://amzn.to/1UTo5SH
Half Dome Climbing Helmet: http://amzn.to/1QfLxZ8
Chalk Bag with Belt and Zippered Pocket: http://amzn.to/1OtW84a
REVERSO 4 Belay Device: http://amzn.to/1F170Vi

Watch more How to Rock Climb videos: http://www.howcast.com/videos/512708-How-to-Dress-for-Indoor-Climbing-Rock-Climbing

When you go into a rock climbing, it’s important to know what to wear. Basically, you want to be comfortable.

A couple things to consider. I like to wear pants when I’m climbing, because when you’re sitting in a harness, it’s just a little bit more comfortable to have that fabric underneath the leg loops. And, also, for doing moves where maybe you’re doing high steps. It’s just kind of nice to have that extra coverage. Certain types of moves, like knee bars as well, it’s nice to have some extra padding.

As far as the material, well, that choice is kind of up to you. There’s lots of folks that like to climb in jeans. Folks who like to climb in athletic pants. But, really, it’s up to you. Whatever’s comfortable. Whatever you can move around in.

Keep in mind, it can get pretty hot while you’re climbing. Jeans might not breath as well. But, if it’s what you’re comfortable in, then by any means, you can climb in jeans.

Sometimes a more durable fabric is a good choice as well. Really thin type wind pants might rip or tear pretty easily. So, try to avoid those.

And shorts are fine, but maybe not too short. If they get caught up underneath your leg loop they’ll get hiked up really quickly. And those short-shorts are going to be really short-shorts pretty soon.

As far as the shirt is concerned, once again, anything comfortable. T-shirts, tank tops. Really, whatever suits your fancy.

So find something comfortable. Find something stylish. And go climbing.

Bicep – Glue & Apricots (Glastonbury 2022)

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GUIDANCE: Contains flashing images

Bicep performs Glue & Apricots at Glastonbury 2022. Go to BBC iPlayer now to watch more.
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DJ Duo BICEP aus Nordirland live im ZOOM in Frankfurt am Main
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Does eczema mean you have a weak immune system?

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Discover if eczema is associated with a weak immune system. This video looks at why sleep deprivation may worsen skin symptoms for more information and tips that may help soothe the skin and improve sleep read my article here: https://www.avogel.co.uk/health/skin/eczema/does-eczema-mean-you-have-a-weak-immune-system
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Calgary Climbing Centre Rocky Mountain Promo Video

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Thanks Wiktor from Latitude Photography for helping us produce this “one shot” promo of our Flagship Climbing Gym in Calgary.
Also, thanks to all the volunteers that helped with this shoot really early in the morning. Can you identify who they were, and how many times they appeared in the shoot?
Subscribe for more videos and updates!

Perfect ADVENTURE for FAMILIES - Calgary Climbing Center

#calgaryclimbingcentre #stufftodoincalgary #calgary2019

Don’t forget to like & subscribe! 👉https://bit.ly/2UcjIsh – And I’ll keep making vids about our awesome city!

Calgary is an AMAZING city with so many great options for adventure and activities for the family, (not even counting the Rockies!) If you live here, and have not yet visited the new Calgary Climbing Centre, you NEED to check it out! My son Lochlan and I visited at the end of March 2019 and brought along our GoPro.

The ClimbPark is a portion of the facility that has been set up for families and kids of all ages, as long as they are 40lbs and up. You don’t have to worry about gear, special shoes, or even any past climbing experience. There is plenty of staff in place to assist everyone with supplied harnesses, and to hook you in and out of the auto-belay system. Seriously, have fun, climb, and when you get to the top, jump down and let the harness slowly lower you down.

We spent an hour climbing and the price was per person. We thought we might need more time, but if you’re not an experienced climber an hour is a great workout, and the kids WILL be tired!

My name is Brad McCallum, and I’m a REALTOR with RE/MAX First, here in Calgary. You can follow me at:

Instagram – https://www.instagram.com/brad.mccallum.remax/

Facebook – https://www.facebook.com/brad.mccallum.remax/

To search ALL available properties for sale in Calgary and area, check out www.calgaryyycrealestate.com!

Did you know that 60% of the homes that go up for sale this year won’t sell? If you’re thinking of selling your home, and aren’t sure where to start, please check out my free Calgary Real Estate Guide for 2019 called “How To Sell in a Buyers Market” – it has my ten top tips for getting the most for your home. You can get it free here! -https://bradmccallum.lpages.co/howtosellinabuyersmarket2019/

Thanks again!
Brad McCallum
RE/MAX First
403.862.4646

Climbing Grades EXPLAINED

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Climbing Grades EXPLAINED

In this short tutorial for rock climbing beginners, I explain how to read, understand, and interpret rock climbing grades or ratings. I cover the meaning behind the Yosemite Decimal System (YDS) for route climbing and the V-Scale or Hueco Scale for bouldering. Both of these rating systems are used in the US to describe the difficulty of routes and boulder problems in both indoor and outdoor climbing. I also go into the PG, PG13, R, and X ratings for outdoor climbs. I hope this video answers any questions new rock climbers may have about climbing grades they have seen in guidebooks, at the climbing gym, or at their outdoor crags and boulders.

Like, comment, and subscribe to support the channel!

Original music by Alex Montgomery.

Happy climbing!

******************************************************************************

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http://www.epictv.com

On today’s Friday Gear Show we’re taking a look at some of the different climbing grading systems that are used around the world. We’re going to be de-coding the numbers, and explaining why different countries use different grades. We’re also going to be giving away a prize, so make sure you comment below the episode.

Check out the La Sportiva Genius here: https://goo.gl/L2aqw3

So… What Do Climbing Grades Even Mean? | Climbing Daily Ep.889

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The Immune System and Cancer: What is Cancer? Video Series

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Normally, immune cells detect and attack cancer cells. But some cancer cells can avoid detection or block an attack. Cancer treatments called immunotherapies help immune cells better detect and kill cancer.

This video has open captions.
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After a lifetime of debilitating infections, Tara Sakraida Parker found answers—and treatment—at Johns Hopkins, through immunologist Antoine Azar and the Center for Adult Primary Immunodeficiency Center.

Visit us: https://www.hopkinsmedicine.org/news/publications/hopkins_medicine_magazine/issues/winter-2019
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Entrenar Biceps y Triceps juntos? (Culturismo)

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Suscríbete Al Canal En Español
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Síguenos en Instagram!!
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#biceps #triceps #pesas

🤔 ¿Qué músculos se deben trabajar en el mismo día? 💪🏻 TRUCO ✅

🤔 ¿Qué músculos se deben trabajar en el mismo día? 💪🏻

¿QUE ENTRENAR CADA DIA DE LA SEMANA? ¿Cómo dividir su entrenamiento, porque hacerlo? TRUCO REVELADO!!

Espero que te ayuden estos consejos!! Te leo en los comentarios!! 💪🏻💪🏻

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IMMUNODEFICIENCIES | IMMUNODEFICIENCY DISORDERS

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Immunodeficiency means immune system is unable to protect the host from disease causing agents or from malignant cells.

#agaricus #immunodeficiency #immunodeficiencydisorders #primaryimmunodeficiency #secondaryimmunodeficiencies

PRIMARY IMMUNODEFICIENCY DISORDERS
https://youtu.be/-azY18Nz6u4

DENDRITIC CELL
https://youtu.be/DJ5On8GRwZw

AGRANULOCYTES
https://youtu.be/fMTpLypZsXA

GRANLOCYTES
https://youtu.be/YFeUI2-jiAY

PHAGOCYTOSIS
https://youtu.be/IoV7f_Iz5-U

Reference
https://amzn.to/3L6VASR
https://amzn.to/37Qg8AJ

Primary immunodeficiency disorders

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This is an overview of primary immunodeficiency disorders.

Graphics were created or adapted from Wikimedia Commons.
This presentation was created using Google Slides.

ADDITIONAL TAGS:
Selective IgA deficiency Hyper IgM syndrome X-linked Bruton’s agammaglobulinemia Common variable immunodeficiency C1 esterase inhibitor 22q112 deletion / DiGeorge Severe combined Wiskott–Aldrich Ataxia–telangiectasia Chronic granulomatous disease Leukocyte adhesion Chédiak–Higashi IgE Job Terminal complement C5-C9 Primary disorders B-cell humoral immunity deficiencies T-cell cellular lymphocyte and cellular phagocytosis Most common primary antibody Dx ↓ levels everything else normal normal IgG IgM B cells Related to CVID → similar arrest of cell differentiation Recurrent mouth airway respiratory infxns GI Giardia treat with abx Recall – mucus membranes still works so most patients are healthy asymptomatic undiagnosed benign Rarely presents severe rapid seconds minutes anaphylactic reaction following transfusion blood or IVIG Pathophys Anti-IgA antibodies against the new foreign Stop transfusion Give IM epi +/- bronchodilators antihistamines pressors mechanical ventilation If necessary give IgA-depleted Antibody class switching differentiation doesn’t work Cause absence CD40 ligand ↑ IgA nl cells Minimal nonselective defense Increased susceptibility recurrent sinopulmonary infxns Viruses encapsulated bacteria Treatment scheduled XLA recessive males only BTK gene mutation defective Bruton tyrosine kinase impaired maturation Ig production Signs/symptoms sinopulm Deficiency in opsonizing IgG otitis sinusitis pneumonia encapsulated Pseudomonas S pneumo Haemophilus Symptoms begin at 3-6 months transplacental maternal fades Small lymphoid tissue tonsils adenoids spleen lymph nodes enteroviral infxn Deficient response Diagnosis IgE Confirm flow cytometry B-cells low might say CD20+ low T-cells normal/high SCIG IVIG maybe prophylactic CVID abnormal plasma Decreased Presents adults children 15-35 yo as early puberty Males females resp lung sinus ear salmonella Campylobacter Giardia presentation lungs bronchiectasis fibrosis IBD-esque chronic diarrhea Less form XLA Need least two No vaccinations Upper lower Normal number B-cells but aka thymic aplasia velocardiofacial syndrome autosomal dominant CATCH-22 syndrome Cardiac defects tet fallot trunc art VSD Abnormal facial features micrognathia wide-spaced eyes low-set ears Thymic hypoplasia absent shadow T-cell deficiency Cleft palate craniofacial deformities Hypocalcemia hypoparathyroid seizures newborn tetany within chromosome 22q11 dev pharyngeal pouches Sx Infections viruses fungus Pneumocystis PCP PCP prophylaxis TMP/SMX bone marrow stem transplant Cure thymus SCID defect often adenosine deaminase failed development dysfunction Usually “bubble boy” no immune system starting 6 months Functionally AIDS Infections bacterial opportunistic PCP crypto candida toxo TB herpes chickenpox CMV PML diarrhea failure thrive Tx TMP/SMX English Wikipedia CC0 via Wikimedia Commons WAS protein Impaired cytoskeleton changes white cells platelets WIPE Infections thrombocytopenic Purpura Fig A Eczema B Bleeding hematoma A ear atopic diseases thrombocytopenia + splenectomy Low survival rates Cerebellar ataxia Incoordination stumbling falling slurred speech Oculocutaneous telangiectasia Recessive disease DNA repair predisp malignancy specific tx IVIG XLR NAPHD oxidase anion superoxides macrophages can ingest not kill catalase-positive organisms create granulomas instead respiratory GI UT skin infections granulomas ulcerations Catalase positive organisms Staph Aspergillus Burkholderia Nocardia Serratia Immune ↑ WBC can’t clear Measure neutrophil superoxide production Flow Dihydrorhodamine nitroblue tetrazolium test negative burst daily TMP/SMX antifungal itraconazole IFN-gamma CD18 integrin leukocyte chemotaxis Neutrophils adhere vessels exit impaired extravasation proliferates skin/mucosal skin GU pulm infections pus wounds high fever Newborns omphalitis inflammation umbilical stump delayed separation cord at 2-3 weeks old Lab WBC cytokines leukocytes high neutrophils Autosomal Lysosomes fuse together large granules neutrophils Peripheral neuropathy albinism skin eyes neutropenia for infections JAK-STAT signaling impairs Th17 proliferation FATED coarse Facies prominent forehead broad nose Abscesses cold noninflammatory containing S aureus Candida retained Teeth hyper-IgE Eosinophilia Derm severe eczema ↑↑ IgE eosinophilia Th17 otherwise membrane attack complex MAC which is required lysis Susceptible gram Neisseria meningococcal gonococcal antibiotics vaccines meningococcal Assembly MAC leads pores that disrupt target leading death hereditary angioedema AD deno excess bradykinin fluid accumulates mucosa trauma stress? ACEi NSAIDs Distinct from anaphylaxis no pruritus urticaria Not allergic mediated antihistamines don’t help GI abd pain n/v/d Resp laryngospasm obstruction increased risk but related
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